A High-throughput Method for Measurement of Glomerular Filtration Rate in Conscious Mice
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چکیده
منابع مشابه
A High-throughput method for measurement of glomerular filtration rate in conscious mice.
The measurement of glomerular filtration rate (GFR) is the gold standard in kidney function assessment. Currently, investigators determine GFR by measuring the level of the endogenous biomarker creatinine or exogenously applied radioactive labeled inulin ((3)H or (14)C). Creatinine has the substantial drawback that proximal tubular secretion accounts for ~50% of total renal creatinine excretion...
متن کاملGlomerular filtration rate determinations in conscious type II diabetic mice.
Diabetic nephropathy is a major cause of end-stage renal disease worldwide. The current studies were performed to determine the later stages of the progression of renal disease in type II diabetic mice (BKS; db/db). Methodology was developed for determining glomerular filtration rate (GFR) in conscious, chronically instrumented mice using continuous intravenous infusion of FITC-labeled inulin t...
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Abstract is NOT available
متن کاملEstimation of glomerular filtration rate in conscious mice using a simplified equation
To develop an expedient procedure for estimating glomerular filtration rate (GFR) in conscious mice, we first established a simple technique for repeated blood collections from the tail vein using a microcapillary tube attached to a 24-gauge needle without the hub. Then, we devised a definition equation for estimation of the GFR using the contrast medium iodixanol as a test tracer. Iodixanol wa...
متن کاملCALL FOR PAPERS Renal Hemodynamics Glomerular filtration rate determinations in conscious type II diabetic mice
Bivona BJ, Park S, Harrison-Bernard LM. Glomerular filtration rate determinations in conscious type II diabetic mice. Am J Physiol Renal Physiol 300: F618–F625, 2011. First published December 8, 2010; doi:10.1152/ajprenal.00421.2010.—Diabetic nephropathy is a major cause of end-stage renal disease worldwide. The current studies were performed to determine the later stages of the progression of ...
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ژورنال
عنوان ژورنال: Journal of Visualized Experiments
سال: 2013
ISSN: 1940-087X
DOI: 10.3791/50330